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Because both berberine and semaglutide lower glucose levels, taking them together may increase the risk of hypoglycemia

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This special interplay further highlights that the loss of any one system can overwhelm the compensatory capacity of the others, forcing the CNS into a state of redox imbalance, glial activation, and progressive inflammation (Figure 1)

References Abd El-Ghafar OA, Hassanein EH, Ali FE, Omar ZM, Rashwan EK, Mohammedsaleh ZM, Sayed AM (2022) Hepatoprotective effect of acetovanillone against methotrexate hepatotoxicity: role of Keap-1/Nrf2/ARE, IL6/STAT-3, and NF-B/AP-1 signaling pathways

Nitric Oxide (NO) pathway: It upregulates nitric oxide synthase, leading to vasodilation, improved blood flow, and reduced inflammation at injury sites