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As expected, the microbial metabolite 5-(3,4-dihydroxyphenyl)--valerolactone appeared later in plasma after 6 h

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47 Taken together, these data suggest the reduced GSH/GSSG antioxidant capacity is insufficient to counter excessive OH production, and that unopposed OH can reach the nucleus to create the oxidative DNA adduct, 8-oxo-dG

Clinical studies demonstrate that GHK-Cu: Improves skin elasticity Reduces fine lines in some cosmetic studies Increases dermal thickness Enhances wound healing in limited models However: Most trials are small Many are cosmetic rather than mechanistic Long-term systemic data are limited Claims regarding hair regrowth and systemic anti aging effects exceed what controlled human trials demonstrate