Alterations of bone biomechanical properties can contribute to osteoporosis and increase the risk of fractures in the elderly
[4] At the cellular level, free estradiol diffuses through cell membranes and binds to intracellular estrogen receptors and , which upon ligand activation dimerize and translocate to estrogen-response elements on nuclear DNA, modulating transcription of genes governing reproductive tract integrity, thermoregulation, bone metabolism, and vascular endothelial function
10.1007/s13346-018-00613-y 6 BolamanZ.KadikoyluG.YukselenV.YavasogluI.BarutcaS.SenturkT
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