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Elevated cAMP further activates the Protein kinase A ( PKA ), which subsequently translocates to the nucleus and phosphorylates cAMP response element binding protein ( CREB )

Lin SH, Myles B, Wei C, Swisher SG , Hofstetter WL, Ajani JA, Ho L, Cox, JD, Komaki R, Liao Z

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Yet, most of the presently utilized models are incapable of reproducing the intricate pathophysiological changes seen in AD