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Melanotan II acts as a non-selective agonist with nanomolar-range affinity at MC1R, MC3R, MC4R, and MC5R, with relative potencies varying by assay system but generally showing highest functional activity at MC1R and MC4R in cAMP accumulation assays using transfected cell lines

18 Despite the overall consistency in demonstrating the glycemic efficacy of GLP-1 RAs and dual GIP/GLP-1 receptor agonists, substantial heterogeneity exists across studies

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