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Result: p53 nuclear exclusion, mitochondrial translocation, and apoptosis
Tirzepatide is the active ingredient in FDA-approved products for diabetes and chronic weight management
10.1007/s00441-019-03016-8 23 HangaiM.YoshimuraN.HiroiK.MandaiM.HondaY
Additional sources of PUFAs for lipid peroxidation include the peroxisome-mediated biosynthesis of plasmalogens through TMEM189 (transmembrane protein 189) in human ovarian and kidney cancer cell lines [93, 94] and lipophagy-mediated lipid droplet degradation in human liver cancer cell lines [95, 96], although the initiation signals for these alternative pathways are not well understood
Phase 2 clinical trials showed some positive outcomes, but these were not sufficiently significant over a treatment period of 7-10 days, leading to the halt of development [11, 12]
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