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As previously said, free radicals destroy skin cells and induce premature ageing, resulting in fine lines, wrinkles, and dark spots

A 2025 pilot study in surgical aortic valve replacement patients reported that cf-mtDNA increased ~16-fold during CPB and that those with higher mtDNA had more postoperative infection and longer hospital stays (33)

Several animal models of cigarette smoke-induced injury have provided evidence that various antioxidants may prevent inflammation and morphological changes associated with COPD however, evidence of benefit in patients is less abundant

64 , e12443 (2018)

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