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Switching from retatrutide to tirzepatide This direction is simpler because you are removing a receptor pathway rather than adding one: Stop retatrutide and allow 1-2 weeks washout Start tirzepatide at 2.5 mg per standard protocol Escalate normally every 4 weeks Expect potentially faster tolerance since your GLP-1 and GIP receptors already have exposure history Some researchers report smoother GI tolerance when switching from a triple to a dual agonist, which makes pharmacological sense
Can I use it long-term
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Keep in mind that while the skinny shot is a helpful tool for weight loss, it works best when combined with a balanced diet and regular exercise routine
Taherian-Fard A, Srihari S, Ragan MA
