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Neither semaglutide nor tirzepatide significantly increased hepatic or pancreatic adverse events in their respective trial programs

Many people find that anchoring to a specific day of the week, the same way you might always do laundry on Sunday, creates a natural rhythm that prevents missed doses

Most patients move through several key phases when adjusting to their maintenance dose: Assessing Your Current State: When youve reached the weight you want to maintain, even if youre still losing, its a good time to talk with your healthcare team about transitioning to a maintenance dose

As a result, more research is necessary to determine whether one drug is more effective than the other for weight loss

Common side effects during the adjustment period (typically the first 24 weeks): Mild nausea usually less intense than when first starting a GLP-1 medication Changes in appetite (some patients notice less appetite suppression early on at the starting 0.25 mg dose) Mild stomach discomfort, bloating, or constipation Injection site reactions Side effects that are less likely during the switch (compared to first-time GLP-1 use), but still possible: Significant vomiting less common given prior GLP-1 exposure, but possible Hypoglycemia particularly relevant for type 2 diabetes patients on insulin or sulfonylureas