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Neelakantan and colleagues (Biochem Pharmacol, 2018) reported that 1-methylquinolinium and 1-methylnicotinamide showed no measurable passive diffusion in their assays, whereas 5-amino-1MQ crossed by both passive and active routes with no detectable efflux in Caco-2 cells, and lowered intracellular 1-methylnicotinamide in differentiated 3T3-L1 adipocytes with an EC near 2.3 M
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10.1378/chest.09-0421 Chest
This work was supported by the National Key Research and Development Program of China (2023YFC2306002), the National Natural Science Foundation of China (82372227 and 82172245), the Beijing Natural Science Foundation (L256024, 7264275), the High-level Talents Program of the Beijing Health System, and Funding for Reform and Development of Beijing Municipal Health Commission (EYGF-BD-03)