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Key pharmaceutical players, including Novo Nordisk and Eli Lilly, are conducting innovative clinical trials, while strategic collaborations with biotech startups accelerate R&D
Substance-use disorders Pre-clinical and mechanistic studies A large body of pre-clinical and mechanistic literature is available regarding the putative effects of GLP-1RAs on substance misuse (Supplementary Section 5): 24 for alcohol 59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82 , 8 for opiates 63,83,84,85,86,87,88,89 , 16 for stimulants, including cocaine and amphetamines 90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105 , and 4 for nicotine 106,107,108,109
4 Hare et al studied ten patients with type-2 diabetes with mean HbA1c of about 7% and ten healthy subjects by giving stepwise increasing GLP-1 infusions on day one or saline on day two with plasma glucose levels clamped at fasting level
In addition, the insulin release stimulated by GLP-1 is glucose-dependent
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