They can disrupt the stomach's natural cleaning waves, especially during fasting [6]
These recommendations are very consistent with the key points from the most current international guidelines, especially those published, in 2024 and 2025, by multi-society groups in both the US and the UK 1-3
Semaglutide's efficacy comes from the peptide itself, demonstrated across major trials (SUSTAIN, STEP programs) showing 15-22% weight loss and cardiovascular benefits at doses from 0.5mg to 2.4mg weekly
Weight loss itselfregardless of the methodcan have profound effects on hormone levels, including sex hormones such as testosterone
*Correspondence: Szymon Drygaa, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers