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A clinically significant subset of subjects developed impaired fasting glucose or frank glucose intolerance, particularly those with pre-existing insulin resistance
This is not a coincidence
Both gut and brain are considered the main organs responsible for controlling body weight
As the research progresses, veterinary professionals can look forward to a potential new tool in their arsenal for managing this challenging condition
The weight-loss effect of GLP-1RAs also benefits NASH improvement, by reducing appetite and increasing energy expenditure to promote weight loss, thereby indirectly ameliorating NASH.206,512 Thus, GLP-1 and its agonists slow down the progression of NASH and may positively impact the reversal of liver fibrosis.513,514 These signaling pathways suggest that GLP-1 and its receptor agonists may influence the progression of NASH through multiple mechanisms, providing several potential therapeutic targets including: FOXO1, a transcription factor that plays a critical role in regulating glucose and lipid metabolism
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