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353 These findings confirm that in the synovium, GLP-1R is expressed on two different cell types, macrophages and fibroblast-like synoviocytes, which are specialized cells distributed within the synovial intima and subintima, and these cell types play important roles in hyaluronic acid synthesis, metabolite processing, and clearance of matrix degradation fragments

Funding This work was supported by the 2020 Basic Medical Research Fund of the Japanese Dermatological Association (donated by Shiseido) (YY)

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Tesamorelin also has human evidence for reducing visceral adiposity and improving liver fat in certain populations, especially in HIV-associated fatty liver patterns