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The GLP-1 agonist exendin-4 attenuates self-administration of sweetened fat on fixed and progressive ratio schedules of reinforcement in rats
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Therefore, therapies targeting only cartilage or synovium may be insufficient
Physical and psychological dependence can develop with regular therapeutic use, though the risk is lower than with recreational misuse
Originally developed for type 2 diabetes, these drugs are now used off-label for PCOS treatment due to their ability to regulate appetite, improve blood sugar levels, and promote weight loss
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