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Research context Research context Intended for non-clinical in vitro studies, this blend is designed to model combined GHRH- and GHSR-axis activation, prolonged and acute GH-axis signaling interactions, and downstream metabolic or secretory responses in controlled laboratory assays

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However, supplementation with exogenous betaine had no significant effect on body weight, composition, or resting energy expenditure (31), indicating that a larger sample size and detailed studies are required for confirmation