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Use of fast-acting insulin within the preceding 12 months was an exclusion criterion because we wished to compare two different strategies of injectable therapy without other concomitant injectable glucose lowering medication

In cultured fibroblasts, GHK-Cu increases synthesis of collagen I and III and of glycosaminoglycans, and modulates the balance of matrix metalloproteinases against their tissue inhibitors (TIMP-1, TIMP-2)

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