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A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling

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It is a driver of multiple co-morbidities such as type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), hypertension, hypercholesterolaemia, cardiovascular disease and cancer ( Oxyntomodulin, a Natural GLP-1 and Glucagon Co-Agonist The journey to discovery of the glucagon family of peptides and an endogenous GLP-1/glucagon co-agonist, oxyntomodulin (OXM) is an example of a concerted effort from many dedicated research groups

MT-II provides a research model for peptide-receptor pharmacology and neuroendocrine signaling dynamics

Important Medical Information and Disclaimers Important Current Status Update : On March 19, 2025, the FDA ended enforcement discretion for compounded tirzepatide