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Classic presentation of multiple myeloma (CRAB) Hyper C alcemia Usually hypercalemia 2/2 lytic bone lesions R enal insufficiency Especially if calcium HIGH, concerning myeloma Since Ca is usually LOW in renal disease A nemia Lytic B one lesions Additional features: Amyloidosis (Big tongue macroglossia, restrictive cardiomyopathy) Hyperviscosity (e.g., WM) Gum bleeding, Epistaxis and Bruising without other explanation Polyneuropathies Pearl 2: What is our initial workup

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While ROS can function as second messengers regulating cellular reproduction, growth, differentiation, and signaling when maintained at optimal concentrations and dynamic equilibrium, exceeding critical ROS thresholds induces oxidative stress, leading to DNA damage, protein denaturation, and lipid peroxidationkey factors in CHD development

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Central fatness and risk of all cause mortality: systematic review and dose-response meta-analysis of 72 prospective cohort studies