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Semaglutide titration: 0.25mg to 2.4mg The semaglutide titration schedule moves through five dose levels over approximately 16-20 weeks: Weeks 1-4: 0.25mg weekly Weeks 5-8: 0.5mg weekly Weeks 9-12: 1.0mg weekly Weeks 13-16: 1.7mg weekly Week 17 onward: 2.4mg weekly (maintenance dose) Each increase happens monthly

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SOX5, sex determining region Y-box protein 5

Support for clinical trials participation in the last five years has been received from Biogen, Alexion, Orion Pharma, WAVE, the EU Horizon 2020 programme and UK NIHR