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Chronic diseases often have immune dysfunction
In fact her boss, Mads Krogsgaard Thomsen, remembers that top management gave them only one year 'to come up with a GLP-1 candidate for daily administration to people with type 2 diabetes' (Holst 2024)
The ranking of therapies is based on their pathway-targeting effectiveness within the DM2-AD comorbidity network, and while metformin demonstrates the highest engagement with key neuroprotective mechanisms, and semaglutide among the least, this does not imply complete inefficacy of lower-ranked therapies
GLP-1 drugs have been found to do so many different things, Vogel said
Semaglutide (GLP-1 only) Targets appetite regulation Slows digestion Improves satiety Effective, but single-pathway Tirzepatide (GLP-1 + GIP) Dual hormone action Enhances insulin sensitivity Stronger appetite suppression More comprehensive metabolic impact The Next Wave: Retatrutide The evolution doesnt stop here
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