doi:10.1111/j.1742-4658.2011.08358.x Richman PG, Meister A (1975) Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione
Thats certainly the case with MOTS-c, a peptide derived from mitochondrial DNA
In accord with the upregulated expression of all the ThDP-dependent dehydrogenases, transcripts of the thiamine/ThDP transporters and the major producer of ThDP from thiamine, i.e., thiamine diphosphokinase (TPK), as well as probable ThMP phosphatase ACP1, also undergo a long-term upregulation (Figure 4B)
It was described in the research literature as the first secretagogue of its kind that does not meaningfully raise cortisol or prolactin, even at doses far above what is needed to release growth hormone (Raun et al., 1998)
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