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Description

Peptides in general are poor substrates and poor inhibitors of cytochrome P450 enzymes because they are typically degraded by proteases rather than hepatic oxidative metabolism [7]

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Concentration refers to the amount of peptide present within a given volume of solution, typically expressed as mg/mL

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AGT is present in the proximal tubule and concurrent increases in AGT-mRNA/protein in renal tissue homogenates has been explained as indicating that transcriptional activation of the AGT gene would be responsible for renal ANG II increase

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