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PloS One (2014) 9:e94433

Saline lacks the benzyl alcohol preservative required for multi-dose vial storage and is not pH-buffered, which increases the risk of choline hydrolysis and methionine oxidation

These trials tracked every reported adverse event, and headaches showed up consistently

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Another GLP-1/GIP/glucagon receptor triagonist known as retatrutide (previously LY3437943) was developed by Eli Lilly in 2022 leading to weight loss, reduced fat mass, decreased blood glucose and insulin levels in obese mice, which was attributed to increased energy expenditure and lipid oxidation [62]