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In addition to energy production, mitochondria perform multiple other functions including Ca 2+ homeostasis [86, 87], generation of ROS [88], regulation of apoptosis [89], activation of endoplasmic reticulum-stress response [90], as well as other far-ranging sequelae of mitochondrial dysfunction [91]

doi:10.1016/j.plaphy.2013.05.032

10.1016/j.cmet.2015.01.003 57 HemauerS

Experimental evidence has demonstrated that a decrease in ascorbic acid levels is tied to GSH depletion [12]

Signals from the brain communicate to the gut mainly through the autonomic nervous system and the hypothalamicpituitary axis to regulate many physiological processes (reviewed elsewhere 20 )