The primary goal was to assess the impact of tirzepatide compared to the placebo on the change in clamp disposition index, which combines measures of insulin secretion and sensitivity
CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals
"GLP-1s can bolster motivation and self-efficacy, making habits easier to adopt, especially in connection with a digital behavior program built specifically for the GLP-1." "We originally built the GLP-1 Companion to mitigate lean mass lossa common side effect of GLP-1 therapy," continued Cook
Study Population The population eligible for inclusion was adults (aged 18.0 years) with both CKD (stage 24 or stage unspecified) and type 2 diabetes who initiated either an SGLT2i or GLP-1 RA in the later period (9 July 2021 [i.e., the FDA approval date of finerenone] to 30 September 2023) with at least 12 months of continuous enrollment before medication initiation (ESM Fig
Semaglutide has become a popular option for weight loss, including for those dealing with menopause-related weight gain