FDA-approved diabetes treatment According to drug manufacturer Novo Nordisk, Ozempic is currently approved for three uses in adults with Type 2 diabetes: Improving blood sugar levels (when used alongside lifestyle changes like diet and exercise) Reducing the risk of heart attack, stroke, and other major cardiovascular disease problems in adults with Type 2 diabetes and heart disease Preventing worsening chronic kidney disease (CKD) and kidney failure in adults with Type 2 diabetes and CKD According to drug manufacturer Eli Lilly, Mounjaro is only approved to improve blood sugar control in adults with Type 2 diabetes
Drugs are not metabolized by the liver, but multidrug and toxin extrusion protein 1 (MATE1) expressed in hepatocytes is involved in the clearance of drugs, which is transported to the kidney through bile or through blood (Gong et al., 2012)
For many of us, these changes can be frustrating, as they can make us feel insecure and less than confident
Accessed November 2, 2023
Am J Physiol - Endocrinol Metab (2008) 294(5):E817E826