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Wearing loose clothing can prevent further irritation, and dont forget to rotate your injection sites
These guidelines, however, do not give a preference regarding which of the second-line agentswhich also include sulfonylureas (SU), dipeptidyl peptidase-4 inhibitors (DPP-IV), sodium-glucose cotransporter 2 inhibitors (SGLT-2i), insulin, thiazolidinediones (TZD) and acarboseshould be added to optimised metformin [13, 14]
The first generation of drugs, such as exenatide, utilized a synthetic version of exendin-4 with a 2.4-hour half-life time, a proof of concept that is now foundational to the field (Knudsen and Lau, 2019)
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