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The STEP 1 trial demonstrated a mean body weight reduction of 14.9% at the 2.4mg maintenance dose over 68 weeks, compared to just 2.4% in the placebo group

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As body weight decreases, hepatic fat content falls, reducing hepatic insulin resistance

Studies have shown improved disease-specific survival with Mohs surgery compared to wide local excision

Simeon 2000 Life Sci simultaneously documented the stimulation of matrix repair and the suppression of degradation by MMP-2 and MMP-9 (matrix metalloproteases), a unique profile of constructive rather than destructive remodelling