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Restored ovulation in previously anovulatory women is a major reason for unexpected pregnancies on GLP-1

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Implications for Clinicians: Prescribing Considerations, Future Generics, and Drug Class Evolution Tirzepatide introduces a new era of incretin-based therapy , and clinicians play a key role in ensuring it is used safely and effectively

Although similar post hoc analyses of the SUSTAIN 6 CVOT have not indicated that indirect mechanisms play a major role for MACE risk reduction [31, 32], exploratory analyses of the LEADER and SUSTAIN 6 trials showed that 25% and 26%, respectively, of kidney-related benefits are mediated by a glucose-lowering effect of GLP-1RAs