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Under hypoxic or hyperglycemic conditions, the accumulation of HIF1 markedly drives renal tubular cell ferroptosischaracterized by HO1/TFRC upregulation, iron overload, and lipid peroxidation
This epigenetic derepression allows senescence-promoting gene expression to increase even when SIRT1 and FOXO3 protein activity is nominally intact a mechanism by which methylation cycle impairment undermines the longevity gene regulatory program from the chromatin level
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The reports indicate that EPA and DHA enhance the therapeutic index of chemotherapeutic drugs by either increasing their efficacy or reducing their toxicity across various cancer types, including breast cancer [91, 92]
Supplementing it, particularly topically, aims to restore some of that youthful regenerative signaling
