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10 Conclusions: route selection, not platform optimism The aspiration to deliver peptides and proteins orally has endured for more than a century, driven by the undeniable practical advantages of oral administration and by successive waves of technological optimism

This makes it challenging to separate drug effects from underlying disease risk in research studies

10.1016/j.apsb.2020.06.016 124 ZhuP.LiJ.FuX.YuZ

These findings are consistent with prior incretin-based therapy studies demonstrating small, transient enzyme elevations without clear clinical significance [24,25,26]

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