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To view or add a comment, sign in For colleagues interested in #tuberculosis treatment and #CNS #pharmacology, Im happy to share that our manuscript, Central nervous system antituberculosis drug exposures in a rabbit model of tuberculous meningitis, has now been published in Antimicrobial Agents and Chemotherapy

The increase in circulating cobalamin levels is predominantly caused by enhanced production of haptocorrin.Several liver diseases like acute hepatitis, cirrhosis, hepatocellular carcinoma and metastatic liver disease can also be accompanied by an increase in circulating cobalamin

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5/5 mg vial + 2 mL BAC water: Concentration = 2,500 mcg BPC-157 + 2,500 mcg TB-500 per mL 250 mcg dose (of each) = 10 units (0.1 mL) on a 100-unit insulin syringe 500 mcg dose (of each) = 20 units (0.2 mL) on a 100-unit insulin syringe Doses per vial: 20 doses at 250 mcg each, or 10 doses at 500 mcg each Supplies Needed (4-Week Loading at 500 mcg/day) 3 vials BPC-157/TB-500 blend (5/5 mg each) provides 30 doses at 500 mcg, covers 28 days with margin 3 vials bacteriostatic water (30 mL each) 30 insulin syringes (2931 gauge, 100-unit) Alcohol prep pads Administration Injection Technique Standard subcutaneous injection

Concurrently, inflamed adipose tissue secretes elevated free fatty acids, pro-inflammatory cytokines, and adipokines that exacerbate hepatic insulin resistance, lipotoxicity, and fibrogenesis [2]