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178,179,180,181,182 Given that DNA damage-activated PARPs account for up to 90% of cellular NAD + consumption, the DNA repair activity is highly dependent on the cellular NAD + concentration

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However, recent advances in EEC-specific transgenic mouse models and single cell RNA sequencing (RNA-seq) studies suggest that EECs exhibit a complex phenotype with multiple hormones expressed in specific EECs and that the similarity of subtypes depends more on EEC location 81

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