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A complete ligament tear, advanced boneonbone arthritis, or severe joint deformity often still requires orthopedic evaluation and, in some cases, surgery

CDA results in macrocytosis, with marked erythroid dysplasia in the bone marrow

Nitro fatty acids Nitro-fatty acids (NO 2 -FAs) are endogenous signalling mediators with strong anti-fibrotic and anti-inflammatory activities [286], able to promote NRF2 activation through the interaction and reversible post-translational modification of C273 and C288 present in the stress sensing domain (IVR) of KEAP1 [287]

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Based on pharmacological principles, this interaction warrants a moderate severity classification