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In ALS, HGF treatment prevents excitotoxic insult through the enhanced expression of glutamate transporter 1 in astrocytes and subsequent clearance of the excessive glutamate (Sun et al., 2002
Further, the model spectra included a macromolecule spectrum acquired from the occipital cortex of 5 volunteers, using an inversion recovery sequence (TR = 3 s, TE = 11 ms, inversion time TI = 0.685 s)
Tumour redox state, hypoxia, and acidosis imaging Tumour microenvironmental characteristics such as hypoxia, altered redox balance, and extracellular acidosis have emerged as central determinants of tumour aggressiveness, metastatic potential, and therapeutic resistance (181, 182)
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GSH abolished this inhibitory effect and promoted the recovery of SLC7A11 and GPX4 levels (Fig
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