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Regarding liver and kidney damage in MTX treatment, Bedoui stated that MTX hepatotoxicity may occur due to the depletion of folate reserves and MTX-polyglutamate formation in the liver (Reference Bedoui, Guillot and Slambarom41)
They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system
Glutathione intravenous (IV) therapy is gaining attention for its potential health benefits, particularly in combating oxidative stress, supporting liver detoxification, boosting immune function, and managing inflammation-related disorders
Large glucose swings, visceral adiposity, fatty liver, and elevated fasting insulin may all signal a metabolic environment that is less favorable for long-term cognitive health
Di Biase N et al
