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SKU: 23258167501

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European Journal of Nutrition, 54 (2), 251263.

Of the six IGFBPs, only IGF-occupied IGFBP-3 and -5 interact with a glycoprotein termed the acid-labile subunit to form ternary complexes which are the major carriers of circulating IGFs, increasing IGF half-life, retarding their extravascular transit to the tissues, and inhibiting their binding to both IGF1R and InsR at the tissue level [17]