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heart failure risk - An FDA warning (4/6/16) was added to saxagliptin regarding an increased risk of heart failure observed in two randomized trials (3.5% risk vs 2.8% for those taking placebo)

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PMID 18348191

Peptides are short chains of amino acids that can act as signaling molecules in the body

When compared to Phentermine, Semaglutide demonstrated significant associations with lower oculomotor binocular dysfunction (HR 0.42, 95% CI: 0.270.66, p = 1 10 4 ), dry eye disease (HR 0.61, 95% CI: 0.380.99, p = 0.044), ametropic accommodative dysfunction (HR 0.44, 95% CI: 0.280.70, p = 3.1 10 4 ), and visual disturbances (HR 0.71, 95% CI: 0.510.98, p = 0.038), while cataracts (HR 0.56, 95% CI: 0.311.00, p = 0.047) and visual issues and blindness (HR 0.77, 95% CI: 0.571.06, p = 0.105) showed borderline or non-significant associations