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Because these two categories act through different proposed pathways, one aimed at the growth-hormone axis and the other at localized tissue repair, this pairing (a secretagogue alongside a repair peptide) is the combination most frequently described across bodybuilding peptide discussions, with the secretagogue framed as supporting muscle and recovery capacity and the repair peptide framed as supporting the joints and connective tissue that sustain harder training

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It also appears in peripheral organs and body fluids, suggesting systemic regulatory functions beyond the central nervous system

The regenerative powers of AOD have also been noted to help individuals who suffer from conditions like osteoarthritis and osteoporosis

doi:10.5664/jcsm.3600 Nieto FJ, Peppard PE, Young T, Finn L, Hla KM, Farre R