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Notably, the inherent susceptibility of pancreatic -cells to ferroptosis provides a mechanistic basis for DM progression, while hyperglycemia reciprocally promotes systemic iron accumulation, thereby establishing a self-reinforcing cycle

According to the latest EASL Clinical Practice Guidelines, non-invasive scores, serum markers, liver stiffness and imaging methods should be used for ruling out rather than diagnosing advanced fibrosis in low-prevalence populations and should be preferentially employed in patients at risk of advanced liver fibrosis (63)

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