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Current biomarker utility is problematic as it exploits high negative predictive values for use in low-prevalence populations (e.g., primary care), and often utilises age as a composite (e.g

The cardiovascular outcome question is the single largest open-source efficacy question in the category and the one most likely to either compress or expand the clinical differentiation between triples, duals, and pure GLP-1 in 2027-2028

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Most users see initial changes by week 2-3 and significant results by week 6-8

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