Modulation of ferritin may enhance the efficacy of conventional therapies (radiotherapy, chemotherapy) by increasing ROS-mediated cytotoxicity, overcoming CSC-driven resistance, and reducing tumor relapse
As mentioned above, ferroptosis could be induced to exert anti-tumor functions via signaling pathway modulation, non-coding RNA expression, DNA methylation, histone modification, CSCs, microenvironment remodeling, and so on
Emerging Pharma Leaders nominations are now open
Phase 1B, randomized, double-blinded, dose escalation, single-center, repeat dose safety and pharmacodynamics study of the oral NLRP3 inhibitor dapansutrile in subjects with NYHA II-III systolic heart failure
Sources Hypoglycemia (low blood glucose)