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Discontinuation rates of 1218% at the highest doses were partially attributed to patients losing more weight than was clinically appropriate for their starting BMI
These reductions in abdominal adiposity correlate with improvements in metabolic parameters, including insulin sensitivity, lipid profiles, and inflammatory markers
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Unfortunately, that popularity proved to be greater than anyone could have imagined
The evidence is mechanistically consistent and promising, but has not reached the level required for FDA approval or clinical guideline inclusion
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