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Beginners, individuals returning to training, and those with higher body fat may be able to gain muscle despite losing weight

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Given the results from recent studies, the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) recommend that patients with T2D and clinical cardiovascular disease (CVD) with inadequate glucose control despite treatment with metformin should receive an SGLT2 inhibitor or GLP-1 receptor agonist

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However, these metabolic benefits are often counterbalanced by complications such as hypoglycemia, stemming from mechanisms like altered nutrient absorption, exaggerated insulin responses, and increased incretin secretion [16, 17]