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However, if that process is somehow interrupted you can end up with free radicals
ApoE4 impairs neuron-astrocyte coupling of fatty acid metabolism
Insulin resistance The brains high sensitivity to insulin is underscored by the abundance of insulin receptors in the hippocampus [210], where insulin signaling regulates synaptic plasticity, neurogenesis, and cognitive function through pathways such as PI3K/AKT, GSK3, and mTOR [211]
Even under linear scaling (an oversimplification), the implied temperature increase would be on the order of 0.00008C
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