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FAQ You may be dangerously constipated and should talk to a clinician right away if you are experiencing any of the following symptoms: Severe abdominal pain Blood in your stool Constipation lasting weeks Unexplained persistent changes in bowel habits Inability or difficulty passing gas Unexplained weight or appetite loss with constipation Vomiting with constipation Feeling a mass in your abdomen Having to use your fingers to extract feces Using an enema or suppository and not being able to evacuate it If you are experiencing extreme constipation, you should talk to a knowledgeable GI provider who can evaluate and treat you and help you find relief as soon as possible

When appetite suppression is steady across 7 days, total caloric reduction over weeks and months is greater than when it fluctuates

doi: 10.1177/17474930221135983 54 YaoMRenYJiaYXuJWangYZouKet al

[Accessed 18 March 2026].