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Other weight-loss medications still in development As research continues, the weight-loss medication landscape is expanding beyond single-hormone GLP-1 treatments

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An increase in AMP/ATP ratio activates AMPK, which phosphorylates the TSC2, and this modification induces the concomitant inhibition of mTORC1 mediated by the TSC1-TSC2 complex [114]

A 2022 analysis of the SUSTAIN and STEP trial data published in Obesity Reviews found a clear and consistent relationship between dose escalation speed and gastrointestinal side effect severity