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Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis

Furthermore, AKT activates HIF-1 to transcriptionally upregulate glycolytic effectors including HKII, PDHK1, and LDHA [12]

It also supports a healthy metabolism, endurance, and recovery

Main exclusion criteria included BMI 20 kg/m2, type 1 diabetes, type 2 diabetes, if previously treated with insulin or with oral hypoglycemic or insulin-sensitizing agents, history of malignancy, and hypopituitarism

Overall, this study hints at the possibility of considering anti-diabetic drugs with weight loss-inducing effects for potential repurposing opportunities in MS