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abnormalities should be investigated
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Another clinical trial in Japan (2022) found that NMN improved muscle insulin sensitivity and reduced fatigue in middle-aged adults[2]
A study of workers (n=117) found that the average peak nighttime melatonin levels for day workers was 15.4 ng/mg creating/hr, and the average peak melatonin for night shift workers was almost 50% less (10.9 ng/mg).[ref] Other sources point to the differences in melatonin due to age
Benoist 2014, PMID 25187433) were retracted in April 2025 (retraction notices PMID 40312092 and PMID 40312093) following a Washington State University investigation that found the lead author altered images across her dissertation and multiple co-authored papers
